by Clinical Neuropsychologist | Wednesday, October 23, 2024 | Dementia
Abstract INTRODUCTION Alzheimer’s disease (AD) features changes in mitochondrial structure and function. Investigators debate where to position mitochondrial pathology within the chronology and context of other AD features. METHODS To address whether...
by Clinical Neuropsychologist | Wednesday, October 23, 2024 | Dementia
Abstract INTRODUCTION The genetic pathways that influence longitudinal heterogeneous changes in Alzheimer’s disease (AD) may provide insight into disease mechanisms and potential therapeutic targets. METHODS Longitudinal endophenotypes from the Alzheimer’s...
by Clinical Neuropsychologist | Wednesday, October 23, 2024 | Dementia
Abstract INTRODUCTION The Alzheimer’s Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core was launched to advance Alzheimer’s disease (AD) and AD-related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our...
by Clinical Neuropsychologist | Wednesday, October 23, 2024 | Dementia
Abstract INTRODUCTION Identifying low-cost, minimally-invasive screening instruments for Alzheimer’s disease (AD) trial enrichment will improve the efficiency of AD trials. METHODS A total of 685 cognitively normal (CN) individuals and individuals with mild...
by Clinical Neuropsychologist | Wednesday, October 23, 2024 | Dementia
Abstract BACKGROUND The magnitudes and patterns of alterations of the white–gray matter (WM–GM) functional connectome in preclinical Alzheimer’s disease (AD), and their associations with amyloid and cognition, remain unclear. METHODS We compared regional WM–GM...
