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The role of polygenic risk in Alzheimer’s disease prediction for African Americans

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract INTRODUCTION African Americans (AAs) face a higher risk of Alzheimer’s disease and related dementias (ADRD) than European Americans (EUs), yet the utility of polygenic risk scores (PRS) in AAs remains underexplored. METHODS A standardized dementia PRS...

Developing a neuropsychiatry curriculum for clinical psychologists and neuropsychologists: An e‐Delphi study

by Clinical Neuropsychologist Online | Tuesday, August 4, 2026 | Neuropsychology (general)

Abstract Neuropsychiatric presentations are common across neurological and mental health services but they are often inadequately covered by core clinical psychology and clinical neuropsychology training. Consequently, we aimed to identify components for a...

Lower cardiac output is a risk factor for faster cerebral atrophy over a 11‐year follow‐up period in APOE‐ε4 carriers

by Clinical Neuropsychologist Online | Tuesday, August 4, 2026 | Dementia

Abstract INTRODUCTION Subclinical lower cardiac output (volume of blood pumped per minute) cross-sectionally relates to smaller cerebral gray matter volumes in older adults. This study relates cardiac output to longitudinal gray matter volumes among middle-aged and...

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes

by Clinical Neuropsychologist Online | Tuesday, August 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 August 2026; doi:10.1038/s41593-026-02367-0Klimmt, Cardoso Gonçalves et al. developed a reproducible human three-dimensional brain tissue model with neurons, astrocytes and microglia, replicating in-vivo-like maturation and...

The compositionality continuum as a principle for studying the neural basis of intelligence

by Clinical Neuropsychologist Online | Tuesday, August 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 August 2026; doi:10.1038/s41593-026-02382-1Compositionality exists on a continuum of increasing complexity rather than as a binary trait. Studying its implementation in simpler biological and artificial systems is the most...
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