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501. How to Be More Confident in Our Data w/ Dr. Ulrich Mayr

by Clinical Neuropsychologist Online | Monday, March 31, 2025 | Neuro Podcasts

Would you rather read the transcript? Click here. In this episode, I talk with Dr. Ulrich Mayr, a cognitive neuroscientist, about the fundamental limitations of current cognitive and neuropsychological testing. We explore the reliability of test scores, the dangers of...

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

by Clinical Neuropsychologist Online | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01923-4Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms...

EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation

by Clinical Neuropsychologist Online | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01922-5Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor...

A streaming brain-to-voice neuroprosthesis to restore naturalistic communication

by Clinical Neuropsychologist Online | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01905-6Naturalistic communication is an aim for neuroprostheses. Here the authors present a neuroprosthesis that restores the voice of a paralyzed person simultaneously with their speaking...

Diagnostic accuracy of plasma p‐tau217/Aβ42 for Alzheimer’s disease in clinical and community cohorts

by Clinical Neuropsychologist Online | Saturday, March 29, 2025 | Dementia

Abstract INTRODUCTION This study was undertaken to evaluate the diagnostic performance of a novel plasma phosphorylated tau (p-tau) 217/amyloid beta (Aβ) 42 ratio test for Alzheimer’s disease (AD). METHODS The diagnostic performance of the Lumipulse G plasma...
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