by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia
Abstract INTRODUCTION The locus coeruleus (LC) is important in coordinating communication between brain regions through its widespread connections. However, the organization of its connections, and its changes with aging and Alzheimer’s disease (AD), remains...
by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia
Abstract INTRODUCTION Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals...
by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia
Abstract INTRODUCTION Post mortem proteomic analysis of Alzheimer’s disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced...
by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia
Dementia, Ahead of Print. Although approaches exist to address challenges in supporting participation of people living with dementia in research, these approaches are rarely evaluated, a critical step to understand their influence on promoting the engagement of people...
by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Neuroscience
Nature Neuroscience, Published online: 12 August 2026; doi:10.1038/s41593-026-02403-zThe authors show that human neurons in bilateral corticolimbic sites fire together, modulated by working memory, and reinstate stimulus-selective firings when both sites briefly...
