by Clinical Neuropsychologist Online | Wednesday, December 11, 2024 | Neuropsychology (general)
Abstract Autobiographical memory is diminished in patients with behavioural variant of frontotemporal dementia (bvFTD), and research has focused on the hampered ability of patients to retrieve specific memories. In this study, we implemented a methodology seeking to...
by Clinical Neuropsychologist Online | Wednesday, December 11, 2024 | Neuroscience
Nature Neuroscience, Published online: 11 December 2024; doi:10.1038/s41593-024-01818-wHow microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting...
by Clinical Neuropsychologist Online | Tuesday, December 10, 2024 | Dementia
Abstract INTRODUCTION This study investigated the impact of trisomy 21 mosaicism (mT21) on Alzheimer’s disease (AD) neuropathology in a well-characterized clinical case described by Ringman et al. METHODS We describe AD neuropathology in mT21 including amyloid...
by Clinical Neuropsychologist Online | Tuesday, December 10, 2024 | Dementia
Abstract INTRODUCTION Recommendations for advance care planning (ACP) in persons with cognitive impairment are based on expert input without insight from actual ACP conversations. METHODS We used thematic analysis to analyze transcripts of ACP conversations for 88...
by Clinical Neuropsychologist Online | Tuesday, December 10, 2024 | Dementia
Abstract INTRODUCTION The SORL1 locus exhibits protective effects against Alzheimer’s disease (AD) across ancestries, yet systematic studies in diverse populations are sparse. METHODS Logistic regression identified AD-associated SORL1 haplotypes in East Asian...
