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EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation

by Clinical Neuropsychologist | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01922-5Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor...

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

by Clinical Neuropsychologist | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01923-4Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms...

Diagnostic accuracy of plasma p‐tau217/Aβ42 for Alzheimer’s disease in clinical and community cohorts

by Clinical Neuropsychologist | Saturday, March 29, 2025 | Dementia

Abstract INTRODUCTION This study was undertaken to evaluate the diagnostic performance of a novel plasma phosphorylated tau (p-tau) 217/amyloid beta (Aβ) 42 ratio test for Alzheimer’s disease (AD). METHODS The diagnostic performance of the Lumipulse G plasma...

Plasma protein risk scores for mild cognitive impairment and Alzheimer’s disease in the Framingham heart study

by Clinical Neuropsychologist | Saturday, March 29, 2025 | Dementia

Abstract INTRODUCTION It is unclear whether aggregated plasma protein risk scores (PPRSs) could be useful in predicting the risks of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). METHODS The Cox proportional hazard model with the Least Absolute...

Accountable care organizations and Medicare payments for residents with ADRD in disadvantaged neighborhoods

by Clinical Neuropsychologist | Saturday, March 29, 2025 | Dementia

Abstract INTRODUCTION Accountable care organizations (ACOs) are well positioned to promote care coordination. However, robust evidence of ACOs’ impact on Medicare payments for residents with Alzheimer’s disease and related dementias (ADRD) in disadvantaged...
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