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Prospects and challenges in using neuronal extracellular vesicles in biomarker research

by Clinical Neuropsychologist Online | Tuesday, July 16, 2024 | Dementia

Abstract Extracellular vesicles (EVs) hold promise as a source of disease biomarkers. The diverse molecular cargo of EVs can potentially indicate the status of their tissue of origin, even against the complex background of whole plasma. The main tools currently...

147| Neuropsych Bite: Redefining Traumatic Brain Injury and Concussion – A Conversation With Dr. Noah Silverberg

by Clinical Neuropsychologist Online | Monday, July 15, 2024 | Neuro Podcasts

Today we give you another conversation with Dr. Noah Silverberg.  This brief episode is on terminology related to the diagnosis of traumatic brain injury and concussion, based on guidance from the American Congress of Rehabilitation Medicine. Show notes are available...

Unlocking opioid neuropeptide dynamics with genetically encoded biosensors

by Clinical Neuropsychologist Online | Monday, July 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 July 2024; doi:10.1038/s41593-024-01697-1Dong et al. developed and validated κLight, δLight and µLight, a suite of genetically encoded opioid peptide sensors for probing opioid drugs and brain-region/circuit-specific opioid...

A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior

by Clinical Neuropsychologist Online | Monday, July 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 July 2024; doi:10.1038/s41593-024-01715-2Parks, Schneider et al. show that brain states like sleep and wake can be reliably detected from milliseconds of neural activity in local regions in mice. Regions can briefly switch...

Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer’s disease continuum

by Clinical Neuropsychologist Online | Saturday, July 13, 2024 | Dementia

Abstract INTRODUCTION Despite parallel research indicating amyloid-β accumulation, alterations in cortical neurophysiological signaling, and multi-system neurotransmitter disruptions in Alzheimer’s disease (AD), the relationships between these phenomena remains...
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