by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience
Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01663-xOligodendrocyte-lineage NG2 glia are shown to limit prion-induced neurodegeneration by quenching toxic microglial responses. Their depletion unleashes prostaglandin E2 secretion by...
by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience
Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01664-wThe axon guidance receptor Plexin-B1 regulates the cellular interaction of peri-plaque astrocytes with microglia to affect the pathophysiology of Alzheimer’s disease. If you do not see...
by Clinical Neuropsychologist Online | Saturday, May 25, 2024 | Dementia
Abstract INTRODUCTION We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (Ktrans) and BBB water exchange rate (kw) varied in cerebral small vessel disease (cSVD) subtypes. METHODS Thirty sporadic cSVD, 40 cerebral autosomal dominant...
by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia
Abstract This perspective offers an alternative to the amyloid hypothesis in the etiology of Alzheimer’s disease (AD). We review evidence for a novel signaling mechanism based on a little-known peptide, T14. T14 could drive neurodegeneration as an aberrantly...
by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia
Abstract INTRODUCTION Patients with subjective memory complaints (SMC) may include subgroups with different neuropsychological profiles and risks of cognitive impairment. METHODS Cluster analysis was performed on two datasets (n: 630 and 734) comprising demographic...
