by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia
Abstract In clinical studies, it is scientifically important, and a regulatory expectation, that objectives be translated into key clinical questions by specifically defining treatment effects to be estimated. Estimands are part of a structured framework, as presented...
by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia
Abstract INTRODUCTION Modifiers of the association between hormone replacement therapy (HRT) use and dementia risk and responsive subgroups, are unknown. METHODS In 183,450 postmenopausal women from the UK Biobank (mean 13.3 years follow-up), multivariable Cox...
by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia
Abstract INTRODUCTION We evaluated whether apolipoprotein E (APOE εε4) genotype-guided lecanemab escalation mitigates the APOE εε4–driven amyloid-related imaging abnormalities (ARIA) with edema (ARIA-E) gradient and whether ARIA-E and ARIA with hemosiderin deposition...
by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia
Abstract INTRODUCTION Few studies have examined the longitudinal associations between chronic stress, social support, and cognitive decline or whether sociodemographic factors modify associations. METHODS We included 3873 older adults enrolled in the Health and Aging...
by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Neuropsychology (general)
Abstract Access to clear, accurate and accessible information is essential for people with disability to exercise choice and control, as outlined in the UN Convention on the Rights of Persons with Disabilities. However, few tools exist to evaluate the quality of...
