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Effects of the active amyloid beta immunotherapy CAD106 on PET measurements of amyloid plaque deposition in cognitively unimpaired APOE ε4 homozygotes

by Clinical Neuropsychologist Online | Friday, March 15, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s Prevention Initiative Generation Study 1 evaluated amyloid beta (Aβ) active immunotherapy (vaccine) CAD106 and BACE-1 inhibitor umibecestat in cognitively unimpaired 60- to 75-year-old participants at genetic risk for...

Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta‐analysis

by Clinical Neuropsychologist Online | Friday, March 15, 2024 | Dementia

Abstract INTRODUCTION The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear. METHODS Using data from eight independent...

Multimorbidity, cognitive phenotypes, and Alzheimer’s disease plasma biomarkers in older adults: A population‐based study

by Clinical Neuropsychologist Online | Friday, March 15, 2024 | Dementia

Abstract INTRODUCTION To examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer’s disease (AD)-related plasma biomarkers among older adults. METHODS This population-based study included 5432...

Unhealthy white matter connectivity, cognition, and racialization in older adults

by Clinical Neuropsychologist Online | Friday, March 15, 2024 | Dementia

Abstract INTRODUCTION White matter hyperintensities (WMH) may promote clinical Alzheimer’s disease (AD) disparities between Black American (BA) and non-Hispanic White (nHW) populations. Using a novel measurement, unhealthy white matter connectivity (UWMC), we...

139| Clinical Case 19 (Adult, Sport Related Concussion) – A Conversation With Dr. Nyaz Didehbani

by Clinical Neuropsychologist Online | Friday, March 15, 2024 | Neuro Podcasts

Today we give you our 19th clinical case and first sport concussion specific case. Nyaz is a neuropsychologist and Associate Professor at UT Southwestern Medical Center. This will be our third conversation with her. We previously discussed chronic traumatic...
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