Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer’s disease neuropathology: Preliminary observations

by | Monday, August 24, 2026 | Dementia

Abstract INTRODUCTION Down syndrome (DS) is caused by a complete or partial trisomy of chromosome 21, resulting in variable intellectual disabilities and a high risk for early-onset Alzheimer’s disease (DS-AD). Dysregulation of the mammalian target of rapamycin...