by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience
Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01850-wNguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA...
by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience
Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01839-5The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value...
by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience
Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01849-3Hehlert et al. report that the gating spring that pulls open mechanosensitive NOMPC channels is not their helical ankyrin tether, but instead an elastic hinge that suspends that...
by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience
Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01847-5This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several...
by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience
Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01833-xMicroglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes...
