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Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia

Abstract INTRODUCTION Post mortem proteomic analysis of Alzheimer’s disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced...

“If She’s Anything Like Me…”: Exploring the Use of Verbally-Prompted Storytelling Techniques in Research With People Living With Dementia

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia

Dementia, Ahead of Print. Although approaches exist to address challenges in supporting participation of people living with dementia in research, these approaches are rarely evaluated, a critical step to understand their influence on promoting the engagement of people...

Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Neuroscience

Nature Neuroscience, Published online: 12 August 2026; doi:10.1038/s41593-026-02403-zThe authors show that human neurons in bilateral corticolimbic sites fire together, modulated by working memory, and reinstate stimulus-selective firings when both sites briefly...

Temporal dissociation of semantic degradation and interference in Alzheimer’s disease: Evidence from Chinese character processing

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Neuropsychology (general)

Abstract Chinese characters serve as the psychological entry point for lexical recognition in reading. Over 80% of these characters are phonetic compounds containing a semantic radical. Understanding how individuals with Alzheimer’s disease (AD) process these...

Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, August 11, 2026 | Dementia

Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer’s disease (AD) risk. In this Perspective article, we propose a stage-informed...
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