Assessing cognitive impairment and disability in older adults through the lens of whole brain white matter patterns

by Clinical Neuropsychologist | Saturday, July 13, 2024 | Dementia

Abstract INTRODUCTION This study aimed to explore the potential of whole brain white matter patterns as novel neuroimaging biomarkers for assessing cognitive impairment and disability in older adults. METHODS We conducted an in-depth analysis of magnetic resonance...

Inequalities in accelerated cognitive decline: Resolving observational window bias using nested non‐linear regression

by Clinical Neuropsychologist | Saturday, July 13, 2024 | Dementia

Abstract INTRODUCTION Limited observational windows lead to conflicting results in studies examining educational differences in Alzheimer’s disease and related dementias (ADRD) risk, due to observational window bias relative to onset of accelerated cognitive...

Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy

by Clinical Neuropsychologist | Friday, July 12, 2024 | Dementia

Abstract INTRODUCTION In tauopathies, altered tau processing correlates with impairments in synaptic density and function. Changes in hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to disease-associated abnormalities in multiple...

The Anne and Henry Zarrow Foundation makes second $5 million grant to Alzheimer’s Association for research

by Clinical Neuropsychologist | Friday, July 12, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | July 12, 2024 Wiley: Alzheimer’s & Dementia: Table...

Spatial extent as a sensitive amyloid‐PET metric in preclinical Alzheimer’s disease

by Clinical Neuropsychologist | Thursday, July 11, 2024 | Dementia

Abstract INTRODUCTION Spatial extent-based measures of how far amyloid beta (Aβ) has spread throughout the neocortex may be more sensitive than traditional Aβ-positron emission tomography (PET) measures of Aβ level for detecting early Aβ deposits in preclinical...

Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults

by Clinical Neuropsychologist | Thursday, July 11, 2024 | Dementia

Abstract INTRODUCTION Older Black adults are at risk of cerebral small vessel disease (CSVD), which contributes to dementia risk. Two subtypes of CSVD, arteriolosclerosis and ischemic lacunar infarcts, have been independently linked to lower cognition and higher...