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Reproductive hormones in relation to white matter hyperintensity volumes among midlife women

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION Although reproductive hormones are implicated in cerebral small vessel disease in women, few studies consider measured hormones in relation to white matter hyperintensity volume (WMHV), a key indicator of cerebral small vessel disease. Even fewer...

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities. METHODS We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in...

Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION The study aimed to investigate the associations of changes in social isolation, loneliness, or both, with cognitive function. METHODS Data were from 7299 older adults in the Chinese Longitudinal Healthy Longevity Survey. We defined four change...

The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract BACKGROUND We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample. METHODS For this retrospective cohort study, data of dementia-free individuals aged 40-69 years were derived from electronic records of the...

Effect of early menopause on cognition and brain morphology in an Urban Indian Cohort

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract BACKGROUND Evidence for the effect of early menopause on cognition among older women is not consistent and is scant among the Indian population. METHODS We aimed to examine the effect of early menopause (≤45 years) on cognitive performance and brain...

Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

by Clinical Neuropsychologist | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION Vervets are non-human primates that share high genetic homology with humans and develop amyloid beta (Aβ) pathology with aging. We expand current knowledge by examining Aβ pathology, aging, cognition, and biomarker proteomics. METHODS Amyloid...
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