by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION There is a need for early, objective markers of Alzheimer’s disease (AD)-related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β-synuclein is elevated in the blood of adults with DS. This study evaluates the...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION Conventional cognitive instruments exhibit limited efficacy in detecting insidious cognitive decline in subjective cognitive decline (SCD) due to neural compensation. We hypothesized that auditory distraction during a visual memory task would...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION In semantic dementia (SD), no consistent prognostic factors for early care home (CH) admission or mortality have been identified, despite their potential utility in care management. METHODS Over a 31-year period, we collected sociodemographic,...
by Clinical Neuropsychologist Online | Tuesday, September 22, 2026 | Dementia
Abstract INTRODUCTION Qualitative models of Alzheimer’s disease (AD) pathology often posit that amyloid accumulation follows a sigmoid curve, indicating that the rate of deposition wanes over time. Longitudinal positron emission tomography (PET) data now allow...
by Clinical Neuropsychologist Online | Monday, September 21, 2026 | Dementia
Abstract INTRODUCTION Cholinergic white matter pathway (CWMP) degeneration is central in Alzheimer’s disease (AD) and Lewy body disease (LBD). CWMP degeneration can be assessed in vivo using magnetic resonance imaging (MRI) proxies, but...
by Clinical Neuropsychologist Online | Monday, September 21, 2026 | Dementia
Abstract INTRODUCTION We assessed the association between cardiovascular disease (CVD) and cognitive decline in adults aged 50 years or older using pooled data from five multinational cohorts, quantified heterogeneity, and explored its potential sources. METHODS...
