Participation in everyday activities among young adult relatives of parents with dementia – A qualitative study

by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia

Dementia, Volume 23, Issue 6, Page 949-963, August 2024. Previous research has shown that young adult relatives of parents with dementia experience strain through increased responsibility and changed relationships in the family with potential consequences for their...

The change of intimate relationship between people with Alzheimer’s disease and their adult child caregivers: An interpretative phenomenological analysis

by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia

Dementia, Volume 23, Issue 7, Page 1063-1080, October 2024. This study aims to explore the change of intimate relationship between people with Alzheimer’s disease and their adult child caregivers as the disease progresses. Twelve adult child caregivers were recruited...

Plasma oxysterols are associated with serum lipids and dementia risk in older women

by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia

Abstract INTRODUCTION Apolipoprotein E4 (APOE4) carriers’ tendency toward hypercholesterolemia may contribute to Alzheimer’s disease (AD) risk through oxysterols, which traverse the blood-brain barrier. METHODS Relationships between baseline plasma oxysterols,...

Data‐driven classification of cognitively normal and mild cognitive impairment subtypes predicts progression in the NACC dataset

by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia

Abstract INTRODUCTION Data-driven neuropsychological methods can identify mild cognitive impairment (MCI) subtypes with stronger associations to dementia risk factors than conventional diagnostic methods. METHODS Cluster analysis used neuropsychological data from...

Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology

by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia

Abstract INTRODUCTION Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains...

Early molecular events of autosomal‐dominant Alzheimer’s disease in marmosets with PSEN1 mutations

by Clinical Neuropsychologist | Friday, April 5, 2024 | Dementia

Abstract INTRODUCTION Fundamental questions remain about the key mechanisms that initiate Alzheimer’s disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically engineered marmosets that carry...