Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, March 26, 2024 | Dementia

Abstract INTRODUCTION Glial fibrillary acidic protein (GFAP) in plasma is a proxy for astrocytic activity and is elevated in amyloid-β (Aβ)-positive individuals, making GFAP a potential blood-based biomarker for Alzheimer’s disease (AD). METHODS We assessed...

Novel ultrasensitive immunoassay for the selective quantification of tau oligomers and related soluble aggregates

by Clinical Neuropsychologist Online | Saturday, March 23, 2024 | Dementia

Abstract INTRODUCTION Tau aggregation into paired helical filaments and neurofibrillary tangles is characteristic of Alzheimer’s disease (AD) and related disorders. However, biochemical assays for the quantification of soluble, earlier-stage tau aggregates are...

Key variants via the Alzheimer’s Disease Sequencing Project whole genome sequence data

by Clinical Neuropsychologist Online | Thursday, March 21, 2024 | Dementia

Abstract INTRODUCTION Genome-wide association studies (GWAS) have identified loci associated with Alzheimer’s disease (AD) but did not identify specific causal genes or variants within those loci. Analysis of whole genome sequence (WGS) data, which interrogates...

The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage

by Clinical Neuropsychologist Online | Wednesday, March 20, 2024 | Dementia

Abstract BACKGROUND Variants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer’s disease (LOAD). METHODS CRISPR-Cas9 was used to generate an Abca7V1613M variant in mice, modeling...

The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage

by Clinical Neuropsychologist Online | Wednesday, March 20, 2024 | Dementia

Abstract BACKGROUND Variants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer’s disease (LOAD). METHODS CRISPR-Cas9 was used to generate an Abca7V1613M variant in mice, modeling...

Dementias Platform UK: Bringing genetics into life

by Clinical Neuropsychologist Online | Wednesday, March 20, 2024 | Dementia

Abstract INTRODUCTION The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is...