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Racial, ethnic, and rural disparities in distance to physicians among decedents with Alzheimer’s disease and related dementias in Washington State

by Clinical Neuropsychologist | Wednesday, March 20, 2024 | Dementia

Abstract INTRODUCTION Distance to physicians may explain some of the disparities in Alzheimer’s disease and related dementia (AD/ADRD) outcomes. METHODS We generated round trip distance between residences of decedents with AD/ADRD and the nearest neurologist and...

Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer’s disease

by Clinical Neuropsychologist | Tuesday, March 19, 2024 | Dementia

Abstract INTRODUCTION Although glymphatic function is involved in Alzheimer’s disease (AD), its potential for predicting the pathological and clinical progression of AD and its sequential association with core AD biomarkers is poorly understood. METHODS...

Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling

by Clinical Neuropsychologist | Tuesday, March 19, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective...

Delineating cognitive resilience using fractal regulation: Cross‐sectional and longitudinal evidence from the Rush Memory and Aging Project

by Clinical Neuropsychologist | Monday, March 18, 2024 | Dementia

Abstract INTRODUCTION Degradation of fractal patterns in actigraphy independently predicts dementia risk. Such observations motivated the study to understand the role of fractal regulation in the context of neuropathologies. METHODS We examined associations of fractal...

Deriving life‐course residential histories in brain bank cohorts: A feasibility study

by Clinical Neuropsychologist | Monday, March 18, 2024 | Dementia

Abstract INTRODUCTION The exposome is theorized to interact with biological mechanisms to influence risk for Alzheimer’s disease but is not well-integrated into existing Alzheimer’s Disease Research Center (ADRC) brain bank data collection. METHODS We...

Wrist‐worn actigraphy in agitated late‐stage dementia patients: A feasibility study on digital inclusion

by Clinical Neuropsychologist | Monday, March 18, 2024 | Dementia

Abstract BACKGROUND Wrist-worn actigraphy can be an objective tool to assess sleep and other behavioral and psychological symptoms in dementia (BPSD). We investigated the feasibility of using wearable actigraphy in agitated late-stage dementia patients. METHODS...
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