by Clinical Neuropsychologist | Tuesday, March 12, 2024 | Dementia
Abstract INTRODUCTION Apolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism...
by Clinical Neuropsychologist | Tuesday, March 12, 2024 | Dementia
Abstract BACKGROUND Impairment of the ubiquitin-proteasome system (UPS) has been implicated in abnormal protein accumulation in Alzheimer’s disease. It remains unclear if genetic variation affects the intrinsic properties of neurons that render some individuals...
by Clinical Neuropsychologist | Sunday, March 10, 2024 | Dementia
Abstract INTRODUCTION Hypertension and diabetes are modifiable risk factors for dementia. We aimed to assess rural-urban disparities in the diagnosis and treatment of these conditions among aging Indians. METHODS Participants (n = 6316) were from two parallel,...
by Clinical Neuropsychologist | Sunday, March 10, 2024 | Dementia
Abstract INTRODUCTION Although dementia-related proteinopathy has a strong negative impact on public health, and is highly heritable, understanding of the related genetic architecture is incomplete. METHODS We applied multidimensional generalized partial credit...
by Clinical Neuropsychologist | Saturday, March 9, 2024 | Dementia
Abstract INTRODUCTION The BIN1 coding variant rs138047593 (K358R) is linked to Late-Onset Alzheimer’s Disease (LOAD) via targeted exome sequencing. METHODS To elucidate the functional consequences of this rare coding variant on brain amyloidosis and...
by Clinical Neuropsychologist | Saturday, March 9, 2024 | Dementia
Abstract Dementia research lacks appropriate representation of diverse groups who often face substantial adversity and greater risk of dementia. Current research participants are primarily well-resourced, non-Hispanic White, cisgender adults who live close to academic...
