Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration

by Clinical Neuropsychologist Online | Wednesday, March 6, 2024 | Dementia

Abstract INTRODUCTION Tau phosphorylated at threonine-217 (pT217-tau) is a novel fluid-based biomarker that predicts onset of Alzheimer’s disease (AD) symptoms, but little is known about how pT217-tau arises in the brain, as soluble pT217-tau is dephosphorylated...

Increased community engagement of Indigenous Peoples in dementia research leads to higher context relevance of results

by Clinical Neuropsychologist Online | Wednesday, March 6, 2024 | Dementia

Dementia, Volume 23, Issue 4, Page 643-668, May 2024. IntroductionHealth research that focuses on Indigenous Peoples must ensure that the community in question is actively engaged, and that the results have context relevance for Indigenous Peoples. Context relevance...

Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia

by Clinical Neuropsychologist Online | Tuesday, March 5, 2024 | Dementia

Abstract INTRODUCTION Magnetic resonance imaging (MRI) biomarkers are needed for indexing early biological stages of Alzheimer’s disease (AD), such as plasma amyloid-β (Aβ42/40) positivity in Aβ positron emission tomography (PET) negative individuals. METHODS...

The experiences and perspectives of older adult mental health professional staff teams when supporting people with young-onset dementia

by Clinical Neuropsychologist Online | Tuesday, March 5, 2024 | Dementia

Dementia, Volume 23, Issue 4, Page 567-583, May 2024. Background. The diagnosis of young-onset dementia presents significant challenges both for the person and their families, which often differ from the challenges faced with late-onset dementia. Evidence of the...

Do people with dementia and carers get what they need? Barriers in social care and carers needs assessments

by Clinical Neuropsychologist Online | Saturday, March 2, 2024 | Dementia

Dementia, Volume 23, Issue 4, Page 550-566, May 2024. BackgroundPeople with dementia and unpaid carers need to go through a social care or carers needs assessment to access and receive subsidised or fully-funded social care. With no previous evidence, this qualitative...

Analysis of agreement between measures of subjective cognitive impairment and probable dementia in the National Health and Aging Trends Study

by Clinical Neuropsychologist Online | Friday, March 1, 2024 | Dementia

Abstract BACKGROUND Subjective cognitive impairment (SCI) measures in population-based surveys offer potential for dementia surveillance, yet their validation against established dementia measures is lacking. METHODS We assessed agreement between SCI and a validated...