Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract INTRODUCTION Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI is critical for comprehending disease progression and enabling preventative intervention. METHODS Patients with MCI...

Neuropsychiatric symptom burden in early‐onset and late‐onset Alzheimer’s disease as a function of age

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract INTRODUCTION We examined the burden of neuropsychiatric symptoms (NPSs) in early-onset (EO) and late-onset (LO) Alzheimer’s disease (AD) and adjusted for age effects via the inclusion of cognitively unimpaired (CU) individuals. METHODS Cross-sectional...

Heterogeneous treatment effects of sodium‐glucose cotransporter 2 inhibitors on risk of dementia in people with type 2 diabetes: A population‐based cohort study

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract INTRODUCTION Sodium-glucose cotransporter 2 (SGLT2) inhibitors exhibit potential benefits in reducing dementia risk, yet the optimal beneficiary subgroups remain uncertain. METHODS Individuals with type 2 diabetes (T2D) initiating either SGLT2 inhibitor or...

Extended genome‐wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer’s disease in individuals of African ancestry

by Clinical Neuropsychologist Online | Wednesday, July 3, 2024 | Dementia

Abstract INTRODUCTION Despite a two-fold risk, individuals of African ancestry have been underrepresented in Alzheimer’s disease (AD) genomics efforts. METHODS Genome-wide association studies (GWAS) of 2,903 AD cases and 6,265 controls of African ancestry....

Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi‐site validation in the MarkVCID Consortium

by Clinical Neuropsychologist Online | Tuesday, July 2, 2024 | Dementia

Abstract INTRODUCTION Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance...

Reproductive hormones in relation to white matter hyperintensity volumes among midlife women

by Clinical Neuropsychologist Online | Monday, July 1, 2024 | Dementia

Abstract INTRODUCTION Although reproductive hormones are implicated in cerebral small vessel disease in women, few studies consider measured hormones in relation to white matter hyperintensity volume (WMHV), a key indicator of cerebral small vessel disease. Even fewer...