by Clinical Neuropsychologist Online | Saturday, July 6, 2024 | Dementia
Abstract INTRODUCTION Understanding longitudinal change in key plasma biomarkers will aid in detecting presymptomatic Alzheimer’s disease (AD). METHODS Serial plasma samples from 424 Wisconsin Registry for Alzheimer’s Prevention participants were analyzed...
by Clinical Neuropsychologist Online | Saturday, July 6, 2024 | Dementia
Abstract INTRODUCTION There is limited evidence regarding the rate of long-term cognitive decline after traumatic brain injury (TBI) among older adults. METHODS In this prospective cohort study, time-varying TBI was defined by self-report and International...
by Clinical Neuropsychologist Online | Saturday, July 6, 2024 | Dementia
Abstract BACKGROUND We investigated the association of peak expiratory flow (PEF) with dementia; cognitive impairment, no dementia (CIND); and transition from CIND to dementia, and possible underlying neuropathological mechanisms. METHODS A population-based cohort of...
by Clinical Neuropsychologist Online | Friday, July 5, 2024 | Dementia
Abstract INTRODUCTION Microtubule (MT) stability is crucial for proper neuronal function. Understanding MT dysregulation is critical for connecting amyloid beta (Aβ) and tau-based degenerative events and early changes in presymptomatic Alzheimer’s disease (AD)....
by Clinical Neuropsychologist Online | Friday, July 5, 2024 | Dementia
Abstract INTRODUCTION Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the...
by Clinical Neuropsychologist Online | Friday, July 5, 2024 | Dementia
Abstract Sex and gender—biological and social constructs—significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer’s disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular disease) which...
