by Clinical Neuropsychologist Online | Saturday, May 25, 2024 | Dementia
Abstract INTRODUCTION We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (Ktrans) and BBB water exchange rate (kw) varied in cerebral small vessel disease (cSVD) subtypes. METHODS Thirty sporadic cSVD, 40 cerebral autosomal dominant...
by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia
Abstract This perspective offers an alternative to the amyloid hypothesis in the etiology of Alzheimer’s disease (AD). We review evidence for a novel signaling mechanism based on a little-known peptide, T14. T14 could drive neurodegeneration as an aberrantly...
by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia
Abstract INTRODUCTION Patients with subjective memory complaints (SMC) may include subgroups with different neuropsychological profiles and risks of cognitive impairment. METHODS Cluster analysis was performed on two datasets (n: 630 and 734) comprising demographic...
by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia
Abstract INTRODUCTION We investigated the association of cognitive reserve (CR) with transitions across cognitive states and death. METHODS This population-based cohort study included 2631 participants (age ≥60 years) who were dementia-free at baseline and regularly...
by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia
Abstract INTRODUCTION Tropomyosin related kinase B (TrkB) and C (TrkC) receptor signaling promotes synaptic plasticity and interacts with pathways affected by amyloid beta (Aβ) toxicity. Upregulating TrkB/C signaling could reduce Alzheimer’s disease (AD)-related...
by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia
Cognitive screening measures are an established part of a dementia assessment and often include measures of subjective difficulties, e.g., Everyday Memory Questionnaire (EMQ), informant-rated difficulty, Cambridge Behavioural Inventory – Revised (CBI-R), and objective...
