Clusters of cognitive performance predict long‐term cognitive impairment in elderly patients with subjective memory complaints and healthy controls

by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia

Abstract INTRODUCTION Patients with subjective memory complaints (SMC) may include subgroups with different neuropsychological profiles and risks of cognitive impairment. METHODS Cluster analysis was performed on two datasets (n: 630 and 734) comprising demographic...

Association of cognitive reserve with transitions across cognitive states and death in older adults: A 15‐year follow‐up study

by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia

Abstract INTRODUCTION We investigated the association of cognitive reserve (CR) with transitions across cognitive states and death. METHODS This population-based cohort study included 2631 participants (age ≥60 years) who were dementia-free at baseline and regularly...

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity‐dependent synaptic and microglial transcriptomic changes in a late‐stage Alzheimer’s mouse model

by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia

Abstract INTRODUCTION Tropomyosin related kinase B (TrkB) and C (TrkC) receptor signaling promotes synaptic plasticity and interacts with pathways affected by amyloid beta (Aβ) toxicity. Upregulating TrkB/C signaling could reduce Alzheimer’s disease (AD)-related...

Measuring Change over Time on Cognitive Screening Measures: An Evaluation of the Psychometric Properties of ACE-III, CBI-R, and EMQ for the Purpose of Dementia Screening

by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia

Cognitive screening measures are an established part of a dementia assessment and often include measures of subjective difficulties, e.g., Everyday Memory Questionnaire (EMQ), informant-rated difficulty, Cambridge Behavioural Inventory – Revised (CBI-R), and objective...

Defining the Role of Frailty in the Transition from Mild Cognitive Impairment to Dementia and in Dementia Progression

by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia

Neurodegenerative diseases are a growing concern in an aging global population. Frailty, often conceptualized as a state of diminished physiological reserve and increased susceptibility to stressors, emerges as a pivotal factor in this context. While frailty may be...

Feeling Alone Together: Loneliness in Older Adults with Cognitive Impairment and Their Family Caregivers with Low Mastery

by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Dementia

Loneliness in older persons with cognitive impairment (PCI) may beget loneliness in their family caregivers, depending on buffering resources caregivers possess. This study examined the association between loneliness in older PCI and loneliness experienced by their...