by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract BACKGROUND The history from a relative or caregiver is an important tool for differentiating neurodegenerative disease. We characterized patterns of caregiver questionnaire responses, at diagnosis and follow-up, on the Cambridge Behavioural Inventory (CBI)....
by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract INTRODUCTION Elevated plasma homocysteine (Hcy) is associated with an increased risk of developing neurodegenerative diseases; however, its relationship with the apolipoprotein E (APOE) ε4 allele has not been well characterized. METHODS Participants...
by Clinical Neuropsychologist | Monday, November 18, 2024 | Dementia
Abstract INTRODUCTION Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory...
by Clinical Neuropsychologist | Monday, November 18, 2024 | Dementia
Abstract INTRODUCTION Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia....
by Clinical Neuropsychologist | Thursday, November 14, 2024 | Dementia
Abstract INTRODUCTION We investigated the effects of multiple cerebrovascular disease (CeVD) neuroimaging markers on brain functional connectivity (FC), and how such CeVD-related FC changes interact with plasma phosphorylated tau (p-tau)181 (an Alzheimer’s...
by Clinical Neuropsychologist | Wednesday, November 13, 2024 | Dementia
Abstract INTRODUCTION We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET)....
