Dorsal raphe tau pathology disrupts sleep‐wake orchestration and sleep architecture in a sex‐specific manner

by Clinical Neuropsychologist Online | Friday, August 7, 2026 | Dementia

Abstract INTRODUCTION Sleep disturbances are frequent symptoms of Alzheimer’s disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin...

A randomized phase 1b/2 trial of ABBV‐916 in adults with early Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, August 7, 2026 | Dementia

Abstract INTRODUCTION ABBV-916, an anti-amyloid immunotherapy, was evaluated in patients with early Alzheimer’s disease (AD). METHODS This phase 1b/2, double-blind, placebo-controlled study consisted of two stages: multiple ascending dose (Stage A) and dose...

Mapping PPA Care: Results of a Survey Study on Speech and Language Therapy for People With Primary Progressive Aphasia Across Germany

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Dementia

Dementia, Ahead of Print. Background:Primary Progressive Aphasia (PPA) is a rare condition characterised by a gradual loss of language due to neurodegenerative processes including frontotemporal lobar degeneration and Alzheimer’s disease. Speech and language therapy...

Lecanemab use in Chinese patients with Alzheimer’s disease: a 12‐month multicenter real‐world study

by Clinical Neuropsychologist Online | Thursday, August 6, 2026 | Dementia

Abstract INTRODUCTION We evaluated lecanemab’s safety and cognitive outcomes in Chinese patients with Alzheimer’s disease (AD) and the utility of blood-based biomarkers (BBMs) for treatment guidance. METHODS A multicenter, real-world cohort enrolled 1042...

Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine‐related dysfunction on tau and its impact on cognition

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract INTRODUCTION Animal models demonstrated that pharmacologically-induced lesioning of the locus coeruleus (LC), the brain’s primary source of norepinephrine, triggered astrocyte reactivity, exacerbating Alzheimer’s disease (AD) pathology and...

Cognitive training and promoting a healthy lifestyle in isolated REM sleep behavior disorder: The randomized controlled trial CogTrAiL‐RBD

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract INTRODUCTION Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked to a high risk for cognitive decline. Therefore, iRBD provides a suitable window for early intervention. METHODS In the...