Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study

by Clinical Neuropsychologist Online | Wednesday, March 26, 2025 | Dementia

Abstract INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (Aβ+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157...

Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis

by Clinical Neuropsychologist Online | Wednesday, March 26, 2025 | Dementia

Abstract INTRODUCTION Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer’s disease (AD). However, evidence in presymptomatic AD remains elusive, underscoring the need for therapies targeting these early...

A ‘personhood paradox’: Care partners’ experiences supporting people with dementia and incontinence

by Clinical Neuropsychologist Online | Saturday, March 22, 2025 | Dementia

Dementia, Ahead of Print. Globally, 50 million people live with dementia and mostly receive care at home. Urinary, faecal and functional incontinence is common in this population and increases care demands. This study explores care partners’ experiences managing...

Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study

by Clinical Neuropsychologist Online | Thursday, March 20, 2025 | Dementia

Abstract INTRODUCTION Neighborhood disadvantage has been shown to impact health and cognitive outcomes, while morphological similarity network (MSN) can elucidate structural morphological patterns underlying cognitive functions. We hypothesized MSNs could provide...

Fibrillar tau alters cerebral endothelial cell metabolism, vascular inflammatory activation, and barrier function in vitro and in vivo

by Clinical Neuropsychologist Online | Thursday, March 20, 2025 | Dementia

Abstract INTRODUCTION The presence of tau aggregates in and around the brain vasculature in Alzheimer’s disease (AD) and tauopathies suggests its possible pathogenicity to cerebral endothelial cells (ECs). METHODS We used an in vitro model of the blood–brain...

Rethinking biological biomarkers to track treatment efficacy in Alzheimer’s disease: Focus on brain connectivity

by Clinical Neuropsychologist Online | Thursday, March 20, 2025 | Dementia

Alzheimer’s &Dementia, Volume 21, Issue 3, March 2025. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Lorenzo Pini, Bruno P Imbimbo | March 20,...