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Platelet‐based therapies in neurodegeneration: Unlocking blood‐brain crosstalk

by Clinical Neuropsychologist | Friday, January 3, 2025 | Dementia

Abstract Understanding the physiological connection between platelets and brain function reveals new paradigms in neurodegenerative disease treatment. Platelets, traditionally associated with hemostasis, but also sometimes regarded as a mirror of neurons in the blood...

miRNA, transcriptional regulation and cognitive decline

by Clinical Neuropsychologist | Friday, January 3, 2025 | Dementia

Abstract Background Despite significant advancements in the development of blood biomarkers for AD, challenges persist due to the complex interplay of genetic and environmental risk factors in AD pathogenesis. Epigenetic processes, including non-coding RNAs and...

Whole genome methylation sequencing in blood from persons with mild cognitive impairment and dementia due to Alzheimer’s disease identifies cognitive status

by Clinical Neuropsychologist | Thursday, January 2, 2025 | Dementia

Abstract INTRODUCTION Whole genome methylation sequencing (WGMS) in blood identifies differential DNA methylation in persons with late-onset dementia due to Alzheimer’s disease (AD) but has not been tested in persons with mild cognitive impairment (MCI). METHODS...

Withdrawn: Understanding the progression of Alzheimer’s Disease in 5XFAD transgenic female mice using 1H‐[13C]‐NMR Spectroscopy

by Clinical Neuropsychologist | Wednesday, January 1, 2025 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | January 1, 2025 Wiley: Alzheimer’s & Dementia:...

Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer’s disease, and primary age‐related tauopathy hippocampi

by Clinical Neuropsychologist | Tuesday, December 31, 2024 | Dementia

Abstract INTRODUCTION Alzheimer’s disease (AD), primary age-related tauopathy (PART), and chronic traumatic encephalopathy (CTE) all feature hyperphosphorylated tau (p-tau)–immunoreactive neurofibrillary degeneration, but differ in neuroanatomical distribution...

Resilience to Alzheimer’s disease associates with alterations in perineuronal nets

by Clinical Neuropsychologist | Tuesday, December 31, 2024 | Dementia

Abstract INTRODUCTION Some individuals show intact cognition despite the presence of neuropathological hallmarks of Alzheimer’s disease (AD). The plasticity of parvalbumin (PV)-containing interneurons might contribute to resilience. Perineuronal nets (PNNs),...
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