by Clinical Neuropsychologist | Friday, December 6, 2024 | Dementia
Abstract INTRODUCTION This study presents a novel multi-view learning approach for machine learning (ML)–based Alzheimer’s disease (AD) diagnosis. METHODS A diffusion model is proposed to synthesize the fluorodeoxyglucose positron emission tomography (FDG PET)...
by Clinical Neuropsychologist | Friday, December 6, 2024 | Dementia
Abstract INTRODUCTION The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is evaluating lifestyle interventions in older adults at risk for cognitive decline and dementia. Here we characterize the baseline data set of...
by Clinical Neuropsychologist | Friday, December 6, 2024 | Dementia
Abstract INTRODUCTION Using a single-nucleus transcriptome derived from the dorsolateral prefrontal cortex of 424 Religious Orders Study and the Rush Memory and Aging Project (ROS/MAP) participants, we investigated the cell type–specific effect of ten vascular...
by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia
Abstract The revised biomarker framework for diagnosis and staging of Alzheimer’s disease (AD) relies on amyloid beta (Aβ) and tau pathologies as core markers, and markers for adjacent pathophysiology, such as neurodegeneration and inflammation. Many of the core...
by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia
Abstract INTRODUCTION The influence of genetic variation on tau protein aggregation, a key factor in Alzheimer’s disease (AD), remains not fully understood. We aimed to identify novel genes associated with brain tau deposition using pathway-based candidate gene...
by Clinical Neuropsychologist | Tuesday, December 3, 2024 | Dementia
Abstract BACKGROUND While cross-sectional studies suggest a link between arteriosclerosis and cognition, longitudinal research is lacking. We investigated how arteriosclerosis in the heart–brain axis is related to cognitive performance trajectories over time. METHODS...
