Alzheimer’s disease‐associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain

by Clinical Neuropsychologist Online | Thursday, December 19, 2024 | Dementia

Abstract INTRODUCTION While there may be microbial contributions to Alzheimer’s disease (AD), findings have been inconclusive. We recently reported an AD-associated CD83(+) microglia subtype associated with increased immunoglobulin G4 (IgG4) in the transverse...

Sex‐specific mechanisms of cerebral microvascular BKCa dysfunction in a mouse model of Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, December 19, 2024 | Dementia

Abstract INTRODUCTION Cerebrovascular dysfunction occurs in Alzheimer’s disease (AD), impairing hemodynamic regulation. Large conductance Ca2+-activated K+ channels (BKCa) regulate cerebrovascular reactivity and are impaired in AD. BKCa activity depends on...

Defining benefit: Clinically and biologically meaningful outcomes in the next‐generation Alzheimer’s disease clinical care pathway

by Clinical Neuropsychologist Online | Thursday, December 19, 2024 | Dementia

Abstract To understand the potential benefits of emerging Alzheimer’s disease (AD) therapies within and beyond clinical trial settings, there is a need to advance current outcome measurements into meaningful information relevant to all stakeholders. The...

Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference

by Clinical Neuropsychologist Online | Wednesday, December 18, 2024 | Dementia

Abstract The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly...

Individual and joint associations between sleep duration and physical activity with cognitive function: A longitudinal analysis among middle‐aged and older adults in China

by Clinical Neuropsychologist Online | Wednesday, December 18, 2024 | Dementia

Abstract INTRODUCTION Studies using cross-sectional data or with a short follow-up period fail to distinguish whether the associations between sleep duration and physical activity with cognitive function result from reverse causation. METHODS The longitudinal study...

Appropriate use of meaningful within‐patient change (MWPC) thresholds in Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, December 18, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Claire J. Lansdall, Jeffrey L. Cummings, Jeffrey Scott Andrews...