Reconstructing Identity in the Shadow of Dementia: Narrative Identity Processes Among Adult Child Caregivers

by Clinical Neuropsychologist Online | Thursday, August 27, 2026 | Dementia

Dementia, Ahead of Print. Caring for a parent with dementia constitutes a profound relational and existential transition for adult children, extending beyond functional caregiving demands to processes of identity negotiation and reconstruction. Although extensive...

“You Don’t Belong in Hospital”: How Hospital-Based Dementia Stigma Shapes Health-Related Quality of Life

by Clinical Neuropsychologist Online | Thursday, August 27, 2026 | Dementia

Dementia, Ahead of Print. Health-related quality of life reflects individuals’ perceptions of how a health condition affects their physical, psychological, and social functioning. Amid increasing pressures on primary care systems, people living with dementia are...

Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer’s disease through machine learning and transcriptomic integration

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract INTRODUCTION Functional brain network alterations associated with Alzheimer’s disease (AD) pathology, including amyloid beta (Aβ) and phosphorylated tau (p-tau), are difficult to interpret due to overlapping aging-associated and non-amyloid biological...

Estimating treatment effects in clinical studies of Alzheimer’s disease: What are estimands and why do we need them?

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract In clinical studies, it is scientifically important, and a regulatory expectation, that objectives be translated into key clinical questions by specifically defining treatment effects to be estimated. Estimands are part of a structured framework, as presented...

Hormone replacement therapy and dementia risk among postmenopausal women: Identifying responsive subgroups in the UK Biobank

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract INTRODUCTION Modifiers of the association between hormone replacement therapy (HRT) use and dementia risk and responsive subgroups, are unknown. METHODS In 183,450 postmenopausal women from the UK Biobank (mean 13.3 years follow-up), multivariable Cox...

APOE‐guided lecanemab dosing dissociates ARIA‐E from ARIA‐H: The K‐ROAD study

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract INTRODUCTION We evaluated whether apolipoprotein E (APOE εε4) genotype-guided lecanemab escalation mitigates the APOE εε4–driven amyloid-related imaging abnormalities (ARIA) with edema (ARIA-E) gradient and whether ARIA-E and ARIA with hemosiderin deposition...