Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine‐related dysfunction on tau and its impact on cognition

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract INTRODUCTION Animal models demonstrated that pharmacologically-induced lesioning of the locus coeruleus (LC), the brain’s primary source of norepinephrine, triggered astrocyte reactivity, exacerbating Alzheimer’s disease (AD) pathology and...

Cognitive training and promoting a healthy lifestyle in isolated REM sleep behavior disorder: The randomized controlled trial CogTrAiL‐RBD

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract INTRODUCTION Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked to a high risk for cognitive decline. Therefore, iRBD provides a suitable window for early intervention. METHODS In the...

Edentulism, blood‐based neurodegenerative biomarkers, and 10‐year dementia risk: A mediation analysis in a nationally representative United States cohort

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract INTRODUCTION Tooth loss is associated with dementia risk, but mechanisms remain unclear. We examined whether blood-based neurodegenerative biomarkers mediate the edentulism–cognition association. METHODS Among 4238 Health and Retirement Study participants...

BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract INTRODUCTION We examined whether locus coeruleus (LC) contrast, an indirect proxy for neuronal density and structural health, was related to delayed episodic memory in healthy older adults (OAs) and those with mild cognitive impairment (MCI) and its...

Temporal order of clinical, imaging, and biomarker changes in frontotemporal lobar degeneration–associated syndromes

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract BACKGROUND The temporal sequence of clinical, imaging, and biological changes in sporadic frontotemporal lobar degeneration (FTLD)–associated syndromes remains poorly characterized, and a comprehensive biomarker cascade model is lacking. METHODS We developed...

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

by Clinical Neuropsychologist Online | Wednesday, August 5, 2026 | Dementia

Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across...