Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases

by Clinical Neuropsychologist Online | Tuesday, November 19, 2024 | Dementia

Abstract INTRODUCTION Elevated plasma homocysteine (Hcy) is associated with an increased risk of developing neurodegenerative diseases; however, its relationship with the apolipoprotein E (APOE) ε4 allele has not been well characterized. METHODS Participants...

Community health workers supporting diverse family caregivers of persons with dementia: Preliminary qualitative results from a randomized home-based study

by Clinical Neuropsychologist Online | Tuesday, November 19, 2024 | Dementia

Dementia, Volume 24, Issue 2, Page 249-268, February 2025. Background and ObjectivesCulturally diverse informal caregivers of community-dwelling persons with dementia face challenges in accessing dementia care resources due to language barriers and cultural stigmas...

Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits

by Clinical Neuropsychologist Online | Monday, November 18, 2024 | Dementia

Abstract INTRODUCTION Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory...

Use of common cardiovascular disease drugs and risk of dementia: A case–control study in Swedish national register data

by Clinical Neuropsychologist Online | Monday, November 18, 2024 | Dementia

Abstract INTRODUCTION Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia....

Additive effects of cerebrovascular disease functional connectome phenotype and plasma p‐tau181 on longitudinal neurodegeneration and cognitive outcomes

by Clinical Neuropsychologist Online | Thursday, November 14, 2024 | Dementia

Abstract INTRODUCTION We investigated the effects of multiple cerebrovascular disease (CeVD) neuroimaging markers on brain functional connectivity (FC), and how such CeVD-related FC changes interact with plasma phosphorylated tau (p-tau)181 (an Alzheimer’s...

Plasma Alzheimer’s disease biomarker variability: Amyloid‐independent and amyloid‐dependent factors

by Clinical Neuropsychologist Online | Wednesday, November 13, 2024 | Dementia

Abstract INTRODUCTION We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET)....