Neurometabolic topography and associations with cognition in Alzheimer’s disease: A whole‐brain high‐resolution 3D MRSI study

by Clinical Neuropsychologist | Monday, July 29, 2024 | Dementia

Abstract INTRODUCTION Altered neurometabolism, detectable via proton magnetic resonance spectroscopic imaging (1H-MRSI), is spatially heterogeneous and underpins cognitive impairments in Alzheimer’s disease (AD). However, the spatial relationships between...

Osteopontin: A novel marker of pre‐symptomatic sporadic Alzheimer’s disease

by Clinical Neuropsychologist | Monday, July 29, 2024 | Dementia

Abstract INTRODUCTION We investigate the role of osteopontin (OPN) in participants with Pre-symptomatic Alzheimer’s disease (AD), mild cognitive impairment (MCI), and in AD brains. METHODS Cerebrospinal fluid (CSF) OPN, AD, and synaptic biomarker levels were...

Structure–function coupling reveals the brain hierarchical structure dysfunction in Alzheimer’s disease: A multicenter study

by Clinical Neuropsychologist | Monday, July 29, 2024 | Dementia

Abstract BACKGROUND Alzheimer’s disease (AD) is a neurodegenerative condition characterized by cognitive decline. To date, the specific dysfunction in the brain’s hierarchical structure in AD remains unclear. METHODS We introduced the structural decoupling...

Book Review: ‘Dignity for Deeply forgetful people: How caregivers can meet the challenges of Alzheimer’s Disease by Stephen Post’

by Clinical Neuropsychologist | Monday, July 29, 2024 | Dementia

Dementia, Volume 23, Issue 8, Page 1416-1418, November 2024. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Lily Haopu Ren | July 29, 2024 SAGE...

Primary lateral sclerosis associated with PSEN1 Pro284Leu variant in a Colombian family: Clinical and neuropathological features

by Clinical Neuropsychologist | Sunday, July 28, 2024 | Dementia

Abstract INTRODUCTION This study investigates primary lateral sclerosis (PLS) as a rare manifestation of the presenilin 1 (PSEN1) NM_000021 c.851C > T p.Pro284Leu variant in three siblings of a Colombian family, outlining its clinical and neuropathological features...

Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts

by Clinical Neuropsychologist | Sunday, July 28, 2024 | Dementia

Abstract INTRODUCTION Subjective cognitive decline (SCD) in amyloid-positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 in the Alzheimer’s disease (AD) continuum, but this requires further validation across cultures, measures, and...