A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging

by Clinical Neuropsychologist | Thursday, October 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 October 2025; doi:10.1038/s41593-025-02067-1Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and...

Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI

by Clinical Neuropsychologist | Thursday, October 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 October 2025; doi:10.1038/s41593-025-02087-xThe brain is constantly monitoring the systems in the body. Here the authors use 7 Tesla functional magnetic resonance imaging to map a large-scale brain system for body regulation...

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes

by Clinical Neuropsychologist | Tuesday, October 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02049-3Zeng et al. show that TDP-43, known for repressing cryptic exon usage in frontotemporal dementia/amyotrophic lateral sclerosis, also controls alternative polyadenylation, impacting...

TDP-43 loss induces cryptic polyadenylation in ALS/FTD

by Clinical Neuropsychologist | Tuesday, October 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02050-wThe authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different...

TDP-43 loss brings RNA to a twist ending

by Clinical Neuropsychologist | Tuesday, October 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02065-3In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent...

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway

by Clinical Neuropsychologist | Monday, October 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 October 2025; doi:10.1038/s41593-025-02074-2Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a...