Mapping human thalamocortical connectivity with electrical stimulation and recording

by Clinical Neuropsychologist | Tuesday, July 15, 2025 | Neuroscience

Nature Neuroscience, Published online: 15 July 2025; doi:10.1038/s41593-025-02009-xIntracranial stimulation maps human brain causal connectivity, uncovering distinct pathways. The authors show that thalamic pulses uniquely evoke delayed theta oscillations, offering...

An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains

by Clinical Neuropsychologist | Monday, July 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 July 2025; doi:10.1038/s41593-025-01987-2Neonatal gyrated brains harbor an elaborate subventricular zone, termed the Arc, supporting cortical migratory streams of diverse interneurons. If you do not see content above, kindly...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease

by Clinical Neuropsychologist | Monday, July 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 July 2025; doi:10.1038/s41593-025-02006-0The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population...

Direct interactions between the human insula and hippocampus during memory encoding

by Clinical Neuropsychologist | Monday, July 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 July 2025; doi:10.1038/s41593-025-02005-1The hippocampus and insula communicate when processing emotional memories. Discrete sites in the human insular cortex showed changes that predicted later memory recall, while others...

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice

by Clinical Neuropsychologist | Tuesday, July 8, 2025 | Neuroscience

Nature Neuroscience, Published online: 08 July 2025; doi:10.1038/s41593-025-01999-yUnlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic...

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

by Clinical Neuropsychologist | Tuesday, July 8, 2025 | Neuroscience

Nature Neuroscience, Published online: 08 July 2025; doi:10.1038/s41593-025-02002-4Time-resolved electron microscopy reveals that intersectin-1 and endophilin A1 condensates hold replacement synaptic vesicles close to release sites. Without this, replacement vesicles...