Microglia-dependent regulation of fear memory extinction

by Clinical Neuropsychologist Online | Monday, May 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02286-0Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories by...

Phasing out animal research prematurely will maintain gender inequities in medicine

by Clinical Neuropsychologist Online | Monday, May 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02309-wDecades of male bias in animal research have left female biology critically understudied. Prematurely phasing out animal research would lock this inequity into future biomedicine,...

A communication subspace relays context-dependent actions from human prefrontal to motor cortex

by Clinical Neuropsychologist Online | Friday, May 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 May 2026; doi:10.1038/s41593-026-02290-4Context-dependent behavior selects actions according to task demands. Using direct brain recordings in humans, Binish et al. uncover how coordinated population activity efficiently...

Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges

by Clinical Neuropsychologist Online | Thursday, April 30, 2026 | Neuroscience

Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02258-4High-density single-neuron recordings in patients with epilepsy revealed interictal discharges are generated by structured laminar circuits. These circuits overlapped with cognitive...

Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation

by Clinical Neuropsychologist Online | Thursday, April 30, 2026 | Neuroscience

Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02263-7The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with...

Down the Rashomon Hole: Reflections on Mapping Emotions in the Brain

by Clinical Neuropsychologist Online | Wednesday, April 29, 2026 | Neuroscience

CNS 2026 guest post by Mohith (Mo) M. Varma Sitting through the four talks at the “Mapping Emotions in the Brain” symposium at the CNS 2026 annual meeting, I couldn’t shake the feeling I was watching the scientific equivalent of Rashomon, Akira Kurosawa’s 1950...