Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

by Clinical Neuropsychologist | Thursday, October 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 October 2024; doi:10.1038/s41593-024-01747-8In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes,...

Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

by Clinical Neuropsychologist | Monday, September 30, 2024 | Neuroscience

Nature Neuroscience, Published online: 30 September 2024; doi:10.1038/s41593-024-01769-2Chen et al. show that subtypes of immune cells in prenatal human brain promote angiogenesis in the germinal matrix. Conversely, in preterm infants, proinflammatory immune cells...

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors

by Clinical Neuropsychologist | Monday, September 30, 2024 | Neuroscience

Nature Neuroscience, Published online: 30 September 2024; doi:10.1038/s41593-024-01773-6Matoba, Le, Valone et al. characterized context-dependent genetic effects on gene regulatory activity during Wnt stimulation, finding that genetic variant function during...

Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation

by Clinical Neuropsychologist | Friday, September 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 September 2024; doi:10.1038/s41593-024-01770-9Jung et al. show that shelter experience boosts dopamine release in the nucleus accumbens, generating a goal-location memory. Reactivating a neuronal ensemble developed from...

Advances and controversies in meningeal biology

by Clinical Neuropsychologist | Friday, September 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 September 2024; doi:10.1038/s41593-024-01701-8The authors review current knowledge of the molecular identity and functions of the dura, arachnoid and pial layers of meninges and controversial aspects of meningeal biology that...

How Threats Shape the Organization of our Memories

by Clinical Neuropsychologist | Thursday, September 26, 2024 | Neuroscience

Bad experiences can shape our lives in unconscious ways. If you, say, tried a new dish at a restaurant and got food poisoning, you may not only avoid that restaurant in the future but potentially that dish, even in other settings. Researchers have documented in many...