The cell-type underpinnings of the human functional cortical connectome

by Clinical Neuropsychologist | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01812-2Here Zhang et al. establish multiscale relationships that link postmortem cell-type distributions with the in vivo functional organization of the human cerebral cortex, as assessed...

A top-down slow breathing circuit that alleviates negative affect in mice

by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Neuroscience

Nature Neuroscience, Published online: 19 November 2024; doi:10.1038/s41593-024-01799-wJhang et al. identify a prefrontal–pontomedullary pathway that slows breathing and reduces anxiety in mice, where the pontine reticular nucleus converts excitatory prefrontal inputs...

A revised view of the role of CaMKII in learning and memory

by Clinical Neuropsychologist | Monday, November 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 November 2024; doi:10.1038/s41593-024-01809-xThe CaMKII holoenzyme was long thought to mediate memory storage via an autophosphorylation reaction that occurs between its subunits at Thr286 (pThr286). This Perspective explains...

Emergence of a brainstem somatosensory tonotopic map for substrate vibration

by Clinical Neuropsychologist | Friday, November 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 November 2024; doi:10.1038/s41593-024-01821-1Lee et al. show that the development of the somatotopic map and the tonotopic map for substrate vibration is shaped by the intrinsic distribution of cutaneous end organs and...

Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices

by Clinical Neuropsychologist | Friday, November 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 November 2024; doi:10.1038/s41593-024-01782-5Brain slices offer an experimental window into human neurophysiology. Using high-density microelectrode array recordings and adeno-associated virus–mediated optogenetics, the...

Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States

by Clinical Neuropsychologist | Thursday, November 14, 2024 | Neuroscience

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of...