Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States

by Clinical Neuropsychologist | Thursday, November 14, 2024 | Neuroscience

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of...

TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model

by Clinical Neuropsychologist | Monday, November 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01777-2Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and...

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

by Clinical Neuropsychologist | Monday, November 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01791-4Using single-nucleus RNA sequencing from 32 donors, researchers identified distinct astrocytic gene expression programs activated across brain regions and Alzheimer’s disease...

Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms

by Clinical Neuropsychologist | Wednesday, November 6, 2024 | Neuroscience

Nature Neuroscience, Published online: 06 November 2024; doi:10.1038/s41593-024-01795-0We used single-soma deep RNA sequencing to generate a high-resolution atlas of human somatosensory dorsal root ganglion neurons. This work revealed human-specific molecular...

Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis

by Clinical Neuropsychologist | Tuesday, November 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01765-6Lesion initiation and progression in multiple sclerosis is a dynamic but unclear process. Here, the authors highlight cell type-specific gene sets characterizing the action lesion...

Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions

by Clinical Neuropsychologist | Tuesday, November 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01796-zLerma-Martin et al. generated a paired single-nucleus RNA sequencing and spatial transcriptomics dataset from subcortical multiple sclerosis lesions, identifying spatial niches and...