Single-cell m6A profiling in the mouse brain uncovers cell type-specific RNA methylomes and age-dependent differential methylation

by Clinical Neuropsychologist | Tuesday, September 24, 2024 | Neuroscience

Nature Neuroscience, Published online: 24 September 2024; doi:10.1038/s41593-024-01768-3The authors perform the first single-cell profiling of m6A in the mouse brain. They uncover relative hypomethylation of microglial mRNA compared to other cell types, and they...

A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans

by Clinical Neuropsychologist | Tuesday, September 24, 2024 | Neuroscience

Nature Neuroscience, Published online: 24 September 2024; doi:10.1038/s41593-024-01772-7Siddiqi et al. identified lesion locations that reduced probability of PTSD. These were connected to a brain circuit in which increased connectivity was associated with PTSD, thus...

Publisher Correction: DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice

by Clinical Neuropsychologist | Tuesday, September 24, 2024 | Neuroscience

Nature Neuroscience, Published online: 24 September 2024; doi:10.1038/s41593-024-01785-2Publisher Correction: DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice If you do not see content above,...

Primate superior colliculus is causally engaged in abstract higher-order cognition

by Clinical Neuropsychologist | Thursday, September 19, 2024 | Neuroscience

Nature Neuroscience, Published online: 19 September 2024; doi:10.1038/s41593-024-01744-xNeuronal recordings show that primate superior colliculus encodes learned abstract visual categories. The authors demonstrate that it plays a causal role in categorization...

Investigating Egocentric Tuning in Hippocampal CA1 Neurons

by Clinical Neuropsychologist | Thursday, September 19, 2024 | Neuroscience

Navigation requires integrating sensory information with a stable schema to create a dynamic map of an animal’s position using egocentric and allocentric coordinate systems. In the hippocampus, place cells encode allocentric space, but their firing rates may also...

Disentangling Temporal and Rate Codes in the Primate Somatosensory Cortex

by Clinical Neuropsychologist | Thursday, September 19, 2024 | Neuroscience

Millisecond-scale temporal spiking patterns encode sensory information in the periphery, but their role in the neocortex remains controversial. The sense of touch provides a window into temporal coding because tactile neurons often exhibit precise, repeatable, and...