DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

by Clinical Neuropsychologist | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01923-4Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms...

EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation

by Clinical Neuropsychologist | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01922-5Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor...

A streaming brain-to-voice neuroprosthesis to restore naturalistic communication

by Clinical Neuropsychologist | Monday, March 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 March 2025; doi:10.1038/s41593-025-01905-6Naturalistic communication is an aim for neuroprostheses. Here the authors present a neuroprosthesis that restores the voice of a paralyzed person simultaneously with their speaking...

Projectome-based characterization of hypothalamic peptidergic neurons in male mice

by Clinical Neuropsychologist | Wednesday, March 26, 2025 | Neuroscience

Nature Neuroscience, Published online: 26 March 2025; doi:10.1038/s41593-025-01919-0This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular...

Integrating multimodal data to understand cortical circuit architecture and function

by Clinical Neuropsychologist | Monday, March 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 March 2025; doi:10.1038/s41593-025-01904-7This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding...

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks

by Clinical Neuropsychologist | Monday, March 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 March 2025; doi:10.1038/s41593-025-01893-7The temporal order of events in working memory is thought to be reflected by ordered neuronal firing at different phases. Here the authors show that this is not the case and that phase...