A common computational and neural anomaly across mouse models of autism

by Clinical Neuropsychologist | Tuesday, June 3, 2025 | Neuroscience

Nature Neuroscience, Published online: 03 June 2025; doi:10.1038/s41593-025-01965-8Noel et al. show aberrant updating of expectations in three distinct mouse models of autism spectrum disorder. Brain-wide neurophysiology data suggest this stems from excess units...

Changing genes, cells and networks to reprogram the brain after stroke

by Clinical Neuropsychologist | Monday, June 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 June 2025; doi:10.1038/s41593-025-01981-8This review explores how stroke induces changes in gene expression, cell behavior and brain networks, offering insights into recovery. It highlights strategies to enhance cellular...

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress

by Clinical Neuropsychologist | Monday, June 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 June 2025; doi:10.1038/s41593-025-01952-zRhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced...

Egocentric value maps of the near-body environment

by Clinical Neuropsychologist | Monday, June 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 June 2025; doi:10.1038/s41593-025-01958-7Some neurons act like body-proximity sensors. The authors show that these neurons reflect the value of contacting or avoiding objects. Together, these neurons compose a flexible...

Microglia eliminate inhibitory synapses and drive neuronal hyperexcitability in epilepsy

by Clinical Neuropsychologist | Friday, May 30, 2025 | Neuroscience

Nature Neuroscience, Published online: 30 May 2025; doi:10.1038/s41593-025-01983-6In mouse models of epilepsy and human brain samples, hyperactive inhibitory signaling from neurons and complement signaling from astrocytes coordinate to drive microglia-mediated...

How Was Your School Day?: Unpacking Free Recall in Young Children

by Clinical Neuropsychologist | Thursday, May 29, 2025 | Neuroscience

School is almost out for summer in many places around the world, and as any parent or teacher knows, asking young kids about how their school day was, or even what they did for the summer, can be a challenge. Many children struggle to freely describe their day to day...