A hippocampal ‘sharp-wave sleep’ state that is dissociable from cortical sleep

by Clinical Neuropsychologist | Thursday, December 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 December 2025; doi:10.1038/s41593-025-02141-8Through continuous multiday recordings in rats, the authors reveal that hippocampal sharp waves reflect sleep need and define a homeostatically regulated sleep state that enables...

Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex

by Clinical Neuropsychologist | Thursday, December 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 December 2025; doi:10.1038/s41593-025-02150-7Human-specific molecular and cellular regulatory programs prolong prefrontal cortical maturation by orchestrating postnatal development of neurons and glia, with implications for...

Electrophysiological classification of human layer 2–3 pyramidal neurons reveals subtype-specific synaptic interactions

by Clinical Neuropsychologist | Wednesday, December 10, 2025 | Neuroscience

Nature Neuroscience, Published online: 10 December 2025; doi:10.1038/s41593-025-02134-7Using multineuron patch clamp in human cortex, the authors uncover four functional subtypes of pyramidal neurons with distinct morphology and subtype-specific synaptic interactions,...

Multi-region m6A epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci

by Clinical Neuropsychologist | Tuesday, December 9, 2025 | Neuroscience

Nature Neuroscience, Published online: 09 December 2025; doi:10.1038/s41593-025-02112-zEpitranscriptomic (m6A) profiling across five human brain regions and developmental stages uncovers region-specific and age-specific dynamics, preferential enrichment in...

Convergent information flows explain recurring firing patterns in cerebral cortex

by Clinical Neuropsychologist | Monday, December 8, 2025 | Neuroscience

Nature Neuroscience, Published online: 08 December 2025; doi:10.1038/s41593-025-02128-5Reproducible cortical firing patterns arise from hierarchical modular networks shaped by distance-dependent connectivity rather than attractor dynamics, suggesting that cortex is...

Patterned wireless transcranial optogenetics generates artificial perception

by Clinical Neuropsychologist | Monday, December 8, 2025 | Neuroscience

Nature Neuroscience, Published online: 08 December 2025; doi:10.1038/s41593-025-02127-6This work presents a fully implantable wireless optogenetic device that delivers spatiotemporally patterned cortical stimulation through the skull and generates artificial...