Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia

by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 September 2024; doi:10.1038/s41593-024-01753-wEarly in Alzheimer’s disease (AD), brain blood flow is reduced by pericytes constricting capillaries. Korte et al. show that oral nimodipine can reverse this and decrease brain...

A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 September 2024; doi:10.1038/s41593-024-01757-6ApoE4 is a risk factor for Alzheimer’s disease and vascular dementia. We report that in ApoE4 mice perivascular macrophages are the sole source and effectors of the ApoE4 mediating...

Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults

by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 September 2024; doi:10.1038/s41593-024-01763-8Gallego-Rudolf et al. report accelerated brain activity with initial amyloid-β deposition in asymptomatic individuals. In those where tau also starts accumulating, brain activity...

Author Correction: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

by Clinical Neuropsychologist | Tuesday, September 17, 2024 | Neuroscience

Nature Neuroscience, Published online: 17 September 2024; doi:10.1038/s41593-024-01776-3Author Correction: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve If you do not see content above, kindly GO TO SOURCE. Not all publishers encode...

Semi-orthogonal subspaces for value mediate a binding and generalization trade-off

by Clinical Neuropsychologist | Tuesday, September 17, 2024 | Neuroscience

Nature Neuroscience, Published online: 17 September 2024; doi:10.1038/s41593-024-01758-5This study shows that the brain can link action to value through neural population subspaces, balancing reliable binding of action to value and generalization to novel stimuli. If...

Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy

by Clinical Neuropsychologist | Monday, September 16, 2024 | Neuroscience

Nature Neuroscience, Published online: 16 September 2024; doi:10.1038/s41593-024-01755-8Tonic and burst-like locus coeruleus firing distinctly tune brain topology toward associative and sensory regions, recruiting both astrocytic and neuronal inhibitory activity. If...