Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis

by Clinical Neuropsychologist | Tuesday, November 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01765-6Lesion initiation and progression in multiple sclerosis is a dynamic but unclear process. Here, the authors highlight cell type-specific gene sets characterizing the action lesion...

Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions

by Clinical Neuropsychologist | Tuesday, November 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01796-zLerma-Martin et al. generated a paired single-nucleus RNA sequencing and spatial transcriptomics dataset from subcortical multiple sclerosis lesions, identifying spatial niches and...

Mapping out multiple sclerosis with spatial transcriptomics

by Clinical Neuropsychologist | Tuesday, November 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01798-xIn this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growing possibilities of spatial transcriptomics by applying it...

The role of motor cortex in motor sequence execution depends on demands for flexibility

by Clinical Neuropsychologist | Monday, November 4, 2024 | Neuroscience

Nature Neuroscience, Published online: 04 November 2024; doi:10.1038/s41593-024-01792-3Motor cortex is required for flexible motor sequences informed by sensory cues but not for single automatic sequences. However, training automatic sequences alongside flexible ones...

Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation

by Clinical Neuropsychologist | Monday, November 4, 2024 | Neuroscience

Nature Neuroscience, Published online: 04 November 2024; doi:10.1038/s41593-024-01794-1Dorsal root ganglia (DRGs) contain a plethora of neuron types. The authors show that the existence of human-specific DRG neuronal types and microneurography recordings reveal...

Astrocytes facilitate brain metastases

by Clinical Neuropsychologist | Monday, November 4, 2024 | Neuroscience

Nature Neuroscience, Published online: 04 November 2024; doi:10.1038/s41593-024-01805-1Astrocytes facilitate brain metastases If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This...