Munc18 modulates syntaxin phase separation to promote exocytosis

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02140-9Syntaxin-1A, a SNARE protein mediating membrane fusion for neurotransmission, forms clusters with unclear functions. Using light-controlled clustering, the authors found that...

A mouse brain atlas based on dendritic microenvironments

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02119-6The authors developed a mouse brain atlas using local dendritic morphological patterns from 101,136 neurons. This representation not only improves anatomical precision but also...

The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02125-8Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis,...

Preconfigured neuronal firing sequences in human brain organoids

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02111-0Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the...

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy

by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02118-7In this study, the authors generated iPSC lines from more than 100 sporadic ALS cases, which recapitulated key disease phenotypes and enabled large-scale drug screening, identifying...

Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function

by Clinical Neuropsychologist | Friday, November 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 November 2025; doi:10.1038/s41593-025-02115-wAstrocytes are associated with Alzheimer’s disease pathogenesis. We found that the transcription factor Sox9 functions to enhance astrocytic phagocytosis of Aβ plaques via MEGF10,...