Neuroanatomical changes observed over the course of a human pregnancy

by Clinical Neuropsychologist | Monday, September 16, 2024 | Neuroscience

Nature Neuroscience, Published online: 16 September 2024; doi:10.1038/s41593-024-01741-0Neural changes in pregnancy are not well understood. Here Pritschet et al. present an open-access precision brain imaging resource, mapping neuroanatomical change in an individual...

Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning

by Clinical Neuropsychologist | Monday, September 16, 2024 | Neuroscience

Nature Neuroscience, Published online: 16 September 2024; doi:10.1038/s41593-024-01767-4Perceptual abilities can be improved by training, up to certain limits. Martin et al. show that vagus nerve stimulation in mice boosts performance on an auditory task via...

DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice

by Clinical Neuropsychologist | Thursday, September 12, 2024 | Neuroscience

Nature Neuroscience, Published online: 12 September 2024; doi:10.1038/s41593-024-01754-9The mechanisms underlying the ability to remyelinate in aging and disease are unclear. Here, the authors show that DOR-mediated activation of α-ketoglutarate in mature...

Myelin lipid metabolism can provide energy for starved axons

by Clinical Neuropsychologist | Thursday, September 12, 2024 | Neuroscience

Nature Neuroscience, Published online: 12 September 2024; doi:10.1038/s41593-024-01750-zWe reveal that lipid turnover in the myelin sheath generates a fatty acid pool in oligodendrocytes that can contribute to the energy balance of white matter tracts. We also...

Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field

by Clinical Neuropsychologist | Thursday, September 12, 2024 | Neuroscience

The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a...

VEGF-A-mediated venous endothelial cell proliferation results in neoangiogenesis during neuroinflammation

by Clinical Neuropsychologist | Tuesday, September 10, 2024 | Neuroscience

Nature Neuroscience, Published online: 10 September 2024; doi:10.1038/s41593-024-01746-9Defective neoangiogenesis and blood–brain barrier leakiness are pathological hallmarks of neuroinflammation. Here the authors show that vascular endothelial growth factor A...