Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis

by Clinical Neuropsychologist Online | Wednesday, March 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 March 2024; doi:10.1038/s41593-024-01613-7Brain region-specific oligodendrocyte population dynamics are unclear. Here the authors implement long-term in vivo three-photon imaging to determine those dynamics in the cortical and...

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

by Clinical Neuropsychologist Online | Wednesday, March 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 March 2024; doi:10.1038/s41593-024-01610-wThe role of TREM1 in neurodegenerative diseases is unclear. Here the authors show that TREM1 promotes cognitive decline in aging and in the context of amyloid pathology in a mouse...

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology

by Clinical Neuropsychologist Online | Wednesday, March 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 March 2024; doi:10.1038/s41593-024-01600-yHuman microglia transplanted in the mouse brain mount a multipronged response to amyloid-β pathology, displaying unique transcriptional states. Alzheimer’s disease risk genes are...

A precision functional atlas of personalized network topography and probabilities

by Clinical Neuropsychologist Online | Tuesday, March 26, 2024 | Neuroscience

Nature Neuroscience, Published online: 26 March 2024; doi:10.1038/s41593-024-01596-5The Masonic Institute for the Developing Brain (MIDB) Precision Brain Atlas is a resource of personalized brain network topographies (n = 9,900). It also provides a probabilistic atlas...

Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

by Clinical Neuropsychologist Online | Monday, March 25, 2024 | Neuroscience

Nature Neuroscience, Published online: 25 March 2024; doi:10.1038/s41593-024-01611-9How genetic information in the germinal zone determines neuronal cell types is unclear. Here the authors show that MEIS2 plays an important role in determining GABAergic neuron...

Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation

by Clinical Neuropsychologist Online | Monday, March 25, 2024 | Neuroscience

Nature Neuroscience, Published online: 25 March 2024; doi:10.1038/s41593-024-01604-8The authors find that Piezo1 stimulation enhances meningeal lymphatics and boosts CSF drainage to treat hydrocephalus and ventriculomegaly, showing promise in Down syndrome and...