The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions

by Clinical Neuropsychologist Online | Monday, March 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 March 2024; doi:10.1038/s41593-024-01598-3Chen et al. show that transitions to innate behaviors, such as feeding and social interaction, rely on their encoding during beta oscillations by neuron populations in the lateral...

Natural language instructions induce compositional generalization in networks of neurons

by Clinical Neuropsychologist Online | Monday, March 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 March 2024; doi:10.1038/s41593-024-01607-5Riveland and Pouget model instructed action, showing that shared structure in task and semantic representations allows language to compose practiced skills in novel settings. Models...

Local origin of excitatory–inhibitory tuning equivalence in a cortical network

by Clinical Neuropsychologist Online | Friday, March 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 March 2024; doi:10.1038/s41593-024-01588-5Cortical excitatory neurons are narrowly tuned to sensory inputs, but the tuning of interneurons is perceived as broad and irregular. Duszkiewicz et al. demonstrate that interneuron...

Liprin-α proteins are master regulators of human presynapse assembly

by Clinical Neuropsychologist Online | Tuesday, March 12, 2024 | Neuroscience

Nature Neuroscience, Published online: 12 March 2024; doi:10.1038/s41593-024-01592-9This paper identifies the evolutionarily conserved liprin-α protein family as key mediators of presynaptic assembly in human neurons. Their recruitment to sites formed by contacting...

In conversation with Igor Adameyko

by Clinical Neuropsychologist Online | Tuesday, March 12, 2024 | Neuroscience

Nature Neuroscience, Published online: 12 March 2024; doi:10.1038/s41593-024-01614-6As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the...

Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

by Clinical Neuropsychologist Online | Monday, March 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 March 2024; doi:10.1038/s41593-024-01595-6A real-time analysis system was developed for an up to 500-megabyte-per-second image stream. This system can extract activities from up to 100,000 neurons in larval zebrafish brains...