Molecular architecture of the human brain vasculature

by Clinical Neuropsychologist | Thursday, September 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 September 2024; doi:10.1038/s41593-024-01759-4Molecular architecture of the human brain vasculature If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at...

Blockade of GluN2B-Containing NMDA Receptors Prevents Potentiation and Depression of Responses during Ocular Dominance Plasticity

by Clinical Neuropsychologist | Thursday, September 5, 2024 | Neuroscience

Monocular deprivation (MD) causes an initial decrease in synaptic responses to the deprived eye in juvenile mouse primary visual cortex (V1) through Hebbian long-term depression (LTD). This is followed by a homeostatic increase, which has been attributed either to...

Distal activity patterns shape the spatial specificity of neurovascular coupling

by Clinical Neuropsychologist | Wednesday, September 4, 2024 | Neuroscience

Nature Neuroscience, Published online: 04 September 2024; doi:10.1038/s41593-024-01756-7The spatial relationship between neuronal and vascular activity remains highly debated. In this study, the authors used multiscale optical imaging to show how vascular architecture...

Inhibitory plasticity supports replay generalization in the hippocampus

by Clinical Neuropsychologist | Tuesday, September 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 September 2024; doi:10.1038/s41593-024-01745-wThe study of neural plasticity has focused on excitatory neural connections, but inhibitory connections can also change. Learning at inhibitory synapses may support high-level...

Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease

by Clinical Neuropsychologist | Tuesday, September 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 September 2024; doi:10.1038/s41593-024-01742-zSingle-cell profiling in the human cortex reveals aging-associated transcriptomic changes across all brain cell types, which overlap with effects with Alzheimer’s disease and show...

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells

by Clinical Neuropsychologist | Thursday, August 29, 2024 | Neuroscience

Nature Neuroscience, Published online: 29 August 2024; doi:10.1038/s41593-024-01743-yComprehensive profiling of a circumventricular organ with leaky blood vessels, and comparison to cortex vasculature reveal that blood–brain barrier heterogeneity reflects differences...