Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells

by Clinical Neuropsychologist | Thursday, August 29, 2024 | Neuroscience

Nature Neuroscience, Published online: 29 August 2024; doi:10.1038/s41593-024-01743-yComprehensive profiling of a circumventricular organ with leaky blood vessels, and comparison to cortex vasculature reveal that blood–brain barrier heterogeneity reflects differences...

Cortical Tagged Synaptic Long-Term Depression in the Anterior Cingulate Cortex of Adult Mice

by Clinical Neuropsychologist | Thursday, August 29, 2024 | Neuroscience

The anterior cingulate cortex (ACC) is a key cortical region for pain perception and emotion. Different forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), have been reported in the ACC. Synaptic tagging of LTP plays an...

Activity of nested neural circuits drives different courtship songs in Drosophila

by Clinical Neuropsychologist | Wednesday, August 28, 2024 | Neuroscience

Nature Neuroscience, Published online: 28 August 2024; doi:10.1038/s41593-024-01738-9Activation of nested, but not discrete, neural circuits drives alternative courtship songs in male Drosophila melanogaster, providing further insight into how the nervous system can...

Going Off Task: Exploring Mind Wandering the Aging Brain

by Clinical Neuropsychologist | Tuesday, August 27, 2024 | Neuroscience

We’ve all experienced it – reading some pages in a book when your mind starts to drift and then realizing that you missed a key point and have to go back and reread the same page. The experience of mind wandering appears throughout our daily lives, whether reading,...

Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress

by Clinical Neuropsychologist | Monday, August 26, 2024 | Neuroscience

Nature Neuroscience, Published online: 26 August 2024; doi:10.1038/s41593-024-01740-1Goodman et al. found that Tau is critical for ROS-induced lipid droplet formation in glia from flies and mammals. Too much or too little glial Tau disrupts lipid droplets, leaving the...

Proteomic changes in Alzheimer disease associated with progressive Aβ plaque and tau tangle pathologies

by Clinical Neuropsychologist | Monday, August 26, 2024 | Neuroscience

Nature Neuroscience, Published online: 26 August 2024; doi:10.1038/s41593-024-01737-wUsing human cerebrospinal fluid proteomics, the authors found that proteins associated with Aβ pathology in Alzheimer disease were mainly expressed in glial cells, whereas those...