Primate superior colliculus is causally engaged in abstract higher-order cognition

by Clinical Neuropsychologist | Thursday, September 19, 2024 | Neuroscience

Nature Neuroscience, Published online: 19 September 2024; doi:10.1038/s41593-024-01744-xNeuronal recordings show that primate superior colliculus encodes learned abstract visual categories. The authors demonstrate that it plays a causal role in categorization...

Investigating Egocentric Tuning in Hippocampal CA1 Neurons

by Clinical Neuropsychologist | Thursday, September 19, 2024 | Neuroscience

Navigation requires integrating sensory information with a stable schema to create a dynamic map of an animal’s position using egocentric and allocentric coordinate systems. In the hippocampus, place cells encode allocentric space, but their firing rates may also...

Disentangling Temporal and Rate Codes in the Primate Somatosensory Cortex

by Clinical Neuropsychologist | Thursday, September 19, 2024 | Neuroscience

Millisecond-scale temporal spiking patterns encode sensory information in the periphery, but their role in the neocortex remains controversial. The sense of touch provides a window into temporal coding because tactile neurons often exhibit precise, repeatable, and...

Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia

by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 September 2024; doi:10.1038/s41593-024-01753-wEarly in Alzheimer’s disease (AD), brain blood flow is reduced by pericytes constricting capillaries. Korte et al. show that oral nimodipine can reverse this and decrease brain...

A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 September 2024; doi:10.1038/s41593-024-01757-6ApoE4 is a risk factor for Alzheimer’s disease and vascular dementia. We report that in ApoE4 mice perivascular macrophages are the sole source and effectors of the ApoE4 mediating...

Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults

by Clinical Neuropsychologist | Wednesday, September 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 September 2024; doi:10.1038/s41593-024-01763-8Gallego-Rudolf et al. report accelerated brain activity with initial amyloid-β deposition in asymptomatic individuals. In those where tau also starts accumulating, brain activity...