A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses

by Clinical Neuropsychologist | Monday, October 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 October 2025; doi:10.1038/s41593-025-02078-yFigge-Schlensok et al. show that leptin-sensitive neurons in the lateral hypothalamus encode anxiogenic stimuli and facilitate adaptive strategies to enable an animal to overcome...

Differential synaptic depression mediates the therapeutic effect of deep brain stimulation

by Clinical Neuropsychologist | Thursday, October 16, 2025 | Neuroscience

Nature Neuroscience, Published online: 16 October 2025; doi:10.1038/s41593-025-02088-wThe authors show that deep brain stimulation (DBS) inhibits local neural activity via differential suppression of glutamate and GABA release, and they developed a chemogenetic...

C9orf72 hexanucleotide repeat expansions impair microglial response in ALS

by Clinical Neuropsychologist | Tuesday, October 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 October 2025; doi:10.1038/s41593-025-02075-1This study shows that C9orf72 mutations impair immune activation in ALS, affecting how brain cells communicate, and highlights key differences in the cellular and molecular pathways...

Region-specific drivers of CSF mobility measured with MRI in humans

by Clinical Neuropsychologist | Tuesday, October 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 October 2025; doi:10.1038/s41593-025-02073-3Brain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain,...

Science must break its silence to rebuild public trust

by Clinical Neuropsychologist | Tuesday, October 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 October 2025; doi:10.1038/s41593-025-02092-0This Comment calls on scientists to acknowledge how insufficient communication and limited engagement beyond academia have deepened the divide between science and the public....

Astrocytic Ca2+ prevents synaptic depotentiation by limiting repetitive activity in dendrites during motor learning

by Clinical Neuropsychologist | Monday, October 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 October 2025; doi:10.1038/s41593-025-02072-4Lai et al. show a function of astrocytic Ca2+ in preventing synaptic depotentiation by reducing repetitive dendritic activity in the motor cortex during motor training, thereby...