Lewy body disease can spread via two distinct body-first routes

by Clinical Neuropsychologist | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01911-8Lewy body disease (LBD) pathology can first spread from the brain or the body. A study of two large postmortem datasets reveals that there are not one but two possible trajectories...

Composing hippocampal maps from cortical building blocks in replay

by Clinical Neuropsychologist | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01909-2We modeled how the hippocampus can construct new cognitive maps from reusable building blocks (structural elements) represented in cortex. This composition supported latent learning...

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration

by Clinical Neuropsychologist | Friday, March 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 March 2025; doi:10.1038/s41593-025-01914-5Targeting the endothelium across ages and neurodegenerative diseases in 92 donors with single-cell inCITE-seq reveals similar alterations in ~40% of capillaries in AD, ALS and FTD....

An axonal brake on striatal dopamine output by cholinergic interneurons

by Clinical Neuropsychologist | Thursday, March 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 March 2025; doi:10.1038/s41593-025-01906-5Cholinergic interneurons act at nicotinic receptors to depress dopamine release, interrupting its relationship to dopamine neuron firing and supporting an inverse scaling of dopamine...

Sympathetic and parasympathetic subtypes of body-first Lewy body disease observed in postmortem tissue from prediagnostic individuals

by Clinical Neuropsychologist | Thursday, March 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 March 2025; doi:10.1038/s41593-025-01910-9This postmortem study identifies brain-first and two body-first subtypes in prediagnostic cases of Lewy body disease. It highlights sympathetic and parasympathetic pathways in...

Expectation-driven sensory adaptations support enhanced acuity during categorical perception

by Clinical Neuropsychologist | Thursday, March 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 March 2025; doi:10.1038/s41593-025-01899-1Bayesian models explain how context biases perceptual behavior toward expected categories, but sensory neurons do not reflect this bias. Instead, expectation sharpens sensory acuity,...