The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine

by Clinical Neuropsychologist | Thursday, May 29, 2025 | Neuroscience

Nature Neuroscience, Published online: 29 May 2025; doi:10.1038/s41593-025-01962-xThe neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of identities. If...

A hypothalamus–brainstem circuit governs the prioritization of safety over essential needs

by Clinical Neuropsychologist | Wednesday, May 28, 2025 | Neuroscience

Nature Neuroscience, Published online: 28 May 2025; doi:10.1038/s41593-025-01975-6Animals need to adapt behavior to balance survival with fulfillment of essential needs. Krauth et al. identify neurons in the lateral hypothalamus that, when activated, prioritize...

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development

by Clinical Neuropsychologist | Wednesday, May 28, 2025 | Neuroscience

Nature Neuroscience, Published online: 28 May 2025; doi:10.1038/s41593-025-01972-9The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP...

What dopamine teaches depends on what the brain believes

by Clinical Neuropsychologist | Wednesday, May 28, 2025 | Neuroscience

Nature Neuroscience, Published online: 28 May 2025; doi:10.1038/s41593-025-01980-9How does the brain learn to predict rewards? In this issue of Nature Neuroscience, Qian, Burrell et al. show that understanding how dopamine guides learning requires knowledge of how...

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy

by Clinical Neuropsychologist | Tuesday, May 27, 2025 | Neuroscience

Nature Neuroscience, Published online: 27 May 2025; doi:10.1038/s41593-025-01979-2The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory...

Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy

by Clinical Neuropsychologist | Tuesday, May 27, 2025 | Neuroscience

Nature Neuroscience, Published online: 27 May 2025; doi:10.1038/s41593-025-01966-7Parhizkar et al. show that lemborexant, an orexin receptor antagonist, protects against neurodegeneration in male tau transgenic mice by preventing tau protein build-up and inflammation,...