Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits

by Clinical Neuropsychologist | Thursday, August 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 August 2025; doi:10.1038/s41593-025-02041-xChronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory deficits,...

FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis

by Clinical Neuropsychologist | Monday, August 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 August 2025; doi:10.1038/s41593-025-02042-wThe Li lab mapped molecularly distinct Purkinje cell (PC) subtypes in 3D and linked them to adult cerebellar architecture. They found that Foxp1/Foxp2 are essential for PC diversity...

Language in the Brain is More Than the Sum of Its Parts

by Clinical Neuropsychologist | Thursday, August 14, 2025 | Neuroscience

When I was young, I remember taking apart a simple flashlight to understand how it works. It seemed to make sense that if you reduce an object down to its parts, you can then see how it all works together. But that is not always the case: some things in the world have...

Turning back the clock on age-related neurodegeneration

by Clinical Neuropsychologist | Wednesday, August 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 August 2025; doi:10.1038/s41593-025-02036-8The embryonic motor neuron selector transcription factors ISL1 and LHX3 can be used to partially rejuvenate the gene expression profile of mature neurons. This process makes neurons...

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific features

by Clinical Neuropsychologist | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02029-7Human-specialized features of immature dentate granule cells (imGCs) formed during adult hippocampal neurogenesis are poorly characterized. Using machine learning-augmented analysis...

Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons

by Clinical Neuropsychologist | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02033-xLowry et al. use embryonic motor neuron selector transcription factors to partially rejuvenate the gene expression profile of mature neurons, making them more resistant to an ALS...