Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease

by Clinical Neuropsychologist | Thursday, January 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 January 2025; doi:10.1038/s41593-024-01866-2Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease...

α-Synuclein deposition in the kidney may contribute to Parkinson’s disease

by Clinical Neuropsychologist | Thursday, January 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 January 2025; doi:10.1038/s41593-024-01867-1During the pathogenesis of Parkinson’s disease (PD), α-synuclein pathology may originate in peripheral organs and spread to the CNS. Using human tissue samples and multiple...

Mapping the cellular etiology of schizophrenia and complex brain phenotypes

by Clinical Neuropsychologist | Monday, January 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 January 2025; doi:10.1038/s41593-024-01834-wDuncan and colleagues link specific human brain cell types to schizophrenia and other complex brain phenotypes, providing mechanistic insights and a cellular taxonomy for psychiatric...

Dynamical constraints on neural population activity

by Clinical Neuropsychologist | Friday, January 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 January 2025; doi:10.1038/s41593-024-01845-7Oby, Degenhart, Grigsby and colleagues used a brain–computer interface to challenge monkeys to override their natural time courses of neural activity. They found the time courses to...

Propagation of neuronal micronuclei regulates microglial characteristics

by Clinical Neuropsychologist | Friday, January 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 January 2025; doi:10.1038/s41593-024-01863-5Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these...

Neural populations are dynamic but constrained

by Clinical Neuropsychologist | Friday, January 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 January 2025; doi:10.1038/s41593-024-01793-2Our brains evolved to help us rapidly learn new things. But anyone who has put in hours of practice to perfect their tennis serve, only to reach a plateau, can attest that our brains...