Turning back the clock on age-related neurodegeneration

by Clinical Neuropsychologist Online | Wednesday, August 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 August 2025; doi:10.1038/s41593-025-02036-8The embryonic motor neuron selector transcription factors ISL1 and LHX3 can be used to partially rejuvenate the gene expression profile of mature neurons. This process makes neurons...

The brain drain puts aging myelin in deep trouble

by Clinical Neuropsychologist Online | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02028-8In this issue, Stamenkovic et al. describe deep in vivo imaging of the brain vasculature to document its evolution during aging, which identifies a unique vulnerability at the site of...

Cross-species analysis of adult hippocampal neurogenesis reveals human-specific features

by Clinical Neuropsychologist Online | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02029-7Human-specialized features of immature dentate granule cells (imGCs) formed during adult hippocampal neurogenesis are poorly characterized. Using machine learning-augmented analysis...

Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons

by Clinical Neuropsychologist Online | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02033-xLowry et al. use embryonic motor neuron selector transcription factors to partially rejuvenate the gene expression profile of mature neurons, making them more resistant to an ALS...

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging

by Clinical Neuropsychologist Online | Tuesday, August 12, 2025 | Neuroscience

Nature Neuroscience, Published online: 12 August 2025; doi:10.1038/s41593-025-02023-zHow reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and...

Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice

by Clinical Neuropsychologist Online | Monday, August 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02032-yActivation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain...