The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex

by Clinical Neuropsychologist Online | Monday, July 28, 2025 | Neuroscience

Nature Neuroscience, Published online: 28 July 2025; doi:10.1038/s41593-025-02004-2This study maps the connections of layer 5 pyramidal neurons in the mouse cortex, revealing distinct local and intercortical wiring patterns, and provides an open framework for...

A neural manifold view of the brain

by Clinical Neuropsychologist Online | Monday, July 28, 2025 | Neuroscience

Nature Neuroscience, Published online: 28 July 2025; doi:10.1038/s41593-025-02031-zRecent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how...

Multimodal cue integration and learning in a neural representation of head direction

by Clinical Neuropsychologist Online | Wednesday, July 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 July 2025; doi:10.1038/s41593-024-01823-zBasnak et al. show that particularly informative spatial cues produce a higher and narrower bump of activity in the Drosophila head direction system. More informative cues can instruct...

Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time

by Clinical Neuropsychologist Online | Wednesday, July 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 July 2025; doi:10.1038/s41593-025-02014-0Atucha et al. provide evidence that noradrenergic activation of the basolateral amygdala facilitates the formation of discrete memories of similar events experienced close in time via a...

Long-range cortical GABA neurons oppose binge drinking

by Clinical Neuropsychologist Online | Wednesday, July 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 July 2025; doi:10.1038/s41593-025-02030-0Binge drinking is widespread, but its underlying cellular mechanisms remain unclear. A recent study identifies a sparse ensemble of GABAergic neurons in the medial orbitofrontal cortex...

Voltage imaging reveals hippocampal inhibitory dynamics shaping pyramidal memory-encoding sequences

by Clinical Neuropsychologist Online | Tuesday, July 22, 2025 | Neuroscience

Nature Neuroscience, Published online: 22 July 2025; doi:10.1038/s41593-025-02016-yUsing voltage imaging, the authors show that interneurons in the hippocampus sharpen memory-encoding-activity by increasing the signal-to-noise ratio of pyramidal neuron sensory...